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KMID : 1160420210030010040
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Epilia: Epilepsy Commun
2021 Volume.3 No. 1 p.40 ~ p.46
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The Effect of Perampanel on Resting-State Electroencephalography Functional Connectivity in Patients with Epilepsy
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Lee Soo-Hyung
Ahn Seon-Jae
Cha Kwang-Su
Lee Sang-Kun
Jung Ki-Young
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Abstract
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Background: The purpose of this study was to investigate the changes in electroencephalography (EEG) functional connectivity (FC) induced by perampanel treatment and to explore the relationship between changes in FC and serum perampanel levels.
Methods: The EEG recordings of 16 patients with epilepsy were used in this study. EEG recordings and neuropsychological tests were performed before and after 25 weeks of perampanel treatment. Serum perampanel levels were also obtained after treatment. FC was measured using the weighted phase lag index (wPLI) and was compared before and after treatment. The correlation between significant changes FC and serum perampanel levels was evaluated.
Results: Eight patients showed a more than 50% reduction in seizure frequency. However, neuropsychological tests showed little change, with only the delayed recall of the Rey Complex Figure showing a significant increase after perampanel treatment. In FC analysis, the wPLI of three electrode pairs (FP1-P3, F8-P3, and P4-Pz) in the alpha band significantly decreased. The changes in the connectivity of the electrode pairs were not correlated with serum perampanel levels.
Conclusions: Although decreases in cognitive function were not observed due to perampanel treatment, significant reductions were observed in alpha band FC, suggesting a potential negative effect on cognition.
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KEYWORD
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Electroencephalography, Epilepsy, Anticonvulsants, Perampanel, Functional connectivity
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